Red wine acts through a familiar drug target

Familiar Old Wine: Great New Bottle

Red wine: A drink to your heart

Mortality and morbidity are still high in cardiovascular disease (CVD). Myocardial ischemia reperfusion injury leading to myocardial infarction is one of the most frequent causes of the death in humans. Atherosclerosis and generation of reactive oxygen species through oxidative stress is the major risk factor for CVD. From the literature collection, it has been identified that moderate consumpt...

Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium

BACKGROUND A greater reduction in cardiovascular risk and vascular protection associated with diet rich in polyphenols are generally accepted; however, the molecular targets for polyphenols effects remain unknown. Meanwhile evidences in the literature have enlightened, not only structural similarities between estrogens and polyphenols known as phytoestrogens, but also in their vascular effects....

Ketamine: a familiar drug we trust.

K ETAMINE, like many other drugs, was the fruit of investigative labors shared by anesthesiologists and pharmacologists, as recently described by Domino in an excellent account of the early years of development and use of this drug. Ketamine was first administered to humans in 1964, and results of that early experience were published in 1965. Now on its way to boasting a 50-yr history of clinic...

Red wine and cardiovascular health.